Do you know what are the MAGIC BULLETS?
As early as early 1900s; Paul Ehrlich proposed the “magic bullet” concept—a substance that could selectively target and destroy disease-causing agents, laying theoretical groundwork!
Most of the time; side effects of a drug is because of lack of specificity! Like you have a simple analgesic which acts on the pain receptors but also on gastric mucosa! So it may relieve pain but can cause gastritis!
This is practically why drugs used in Chemotherapy have many side effects since they also act on normal cells! It is the same even in medications such as in allergy where medications do give relief but cause side effects!
The MAGIC BULLETS concept thus are developed in such a way that these medications specifically act only on the cells causing the problems and sparing the normal cells!
These drugs are now the forefront of cancer and allergy and immunology treatments! They are technically called the MONOCLONAL ANTIBODIES or mAbs!
The history of monoclonal antibodies (mAbs) began with early concepts of “magic bullets,” as above but truly launched in 1975 when Georges Köhler and César Milstein developed the hybridoma technique, allowing the production of identical antibodies against specific targets, earning them the 1984 Nobel Prize!
This breakthrough led to the first FDA-approved mAb, Muromonab-CD3, in 1986 for transplant rejection, paving the way for modern therapies that now treat many diseases, with continuous innovation moving towards humanized and more effective antibody designs!
Now these are basically laboratory-made proteins designed to mimic or enhance the immune system’s ability to fight specific targets, such as cancer cells, viruses, or proteins causing inflammation!
Monoclonal antibodies treat diseases through several distinct methods like flagging Cells, or Blocking Signals or Delivering Payloads or Neutralization They bind to viruses or toxins to prevent them from entering or harming human cells!
With these amazing features the mAbs have now become one of the best inventions of modern medicine as close to the discovery of penicillin!
One of their actions is to bind to two different targets—one on a cancer cell and one on an immune cell—bringing them together to facilitate destruction!
Meaning they can use the body’s own defense system to fight the disease! They are like the secret cells or informants!
They have now found wide use in the fields of Oncology, Autoimmune Disorders and even Infectious Diseases!
They have also been used by allergologists (like the person writing this blog!) in the treatment of chronic issues like allergic bronchitis and sinusitis!
They have been approved for allergic asthma, chronic hives, and nasal polyps!
They have been found to be highly specific in targeting of allergy-driving molecules and significantly improvement in quality of life for many patients.
In short; Magic Bullets!
Talking about Bullets or Goli reminds me of Kalia aka Viju Khote!
Now have a magic sleep!
Shubh ratri!
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